4-Aminophenol fundamental organic compound in the chemical industry is aminophenol (para-aminophenol). Its dual functionality—having both an amino (-NH₂) and a hydroxyl (-OH) group on a benzene ring—underlies its adaptability in a variety of applications, including coatings, dyes, and pharmaceuticals.
Chemical Identity & Structure
- IUPAC Name: 4-Aminophenol (para-Aminophenol, p-aminophenol)
- Molecular Formula: C₆H₇NO
- Molecular Weight: ~109.13 g/mol
- CAS Number: 123-30-8
- EC Number: 204-616-2
- Appearance: A white to off-white crystalline powder; moderately soluble in alcohols and water, and prone to oxidation under air, moisture, or light.
- Structural Highlights: The para positioning (1,4 arrangement) of the amine and hydroxyl groups makes it one of three aminophenol isomers (others being ortho- and meta-).
Synthesis Methods
The conventional method involves employing iron and acid to reduce nitrated phenol compounds, such as p-nitrophenol.
The modern method is the one-step, more environmentally friendly catalytic hydrogenation of nitrobenzene in acidic media using noble metal catalysts.
Key Applications of 4-Aminophenol
1. Pharmaceutical Industry:
- Paracetamol (acetaminophen), one of the most popular analgesics and antipyretics in the world, requires it as a precursor.
- Other : Used in the production of sorafenib, ambroxol, and acebutolol, among other downstream pharmaceutical ingredients.
2. Photography
- 4-aminophenol, marketed under the name Rodinal, is a traditional black-and-white film developing agent that is prized for its image quality and stability.
- Serves as a key building block for azo dyes via diazotization and coupling, widely used in textiles, inks, and plastics for vivid, long-lasting color.
4. Coatings & Corrosion Protection
- In coatings technology, para-aminophenol enhances adhesion, durability, and corrosion resistance—especially in demanding sectors like automotive, aerospace, marine, and construction.
5. Other Industrial Roles
- Acts as a corrosion inhibitor in paints and lubricants, and as a wood stain imparting a rose-like tint.
- Employed as a reagent in analytical chemistry for detecting metals (e.g., copper, vanadium) and compounds such as nitrites and cyanates.
6. Hair Dye Industry
- Used as a precursor in oxidative hair dyes, typically limited to a maximum concentration of ~0.9% when mixed with oxidizing agents to ensure safety and efficacy.
Physicochemical Properties & Safety Profile
| Property | Value / Details |
| Melting Point | ~190 °C |
| Boiling Point | ~284 °C (with decomposition) |
| Log P | ~0.04 (slightly hydrophilic) |
| Hazards | Harmful if ingested or inhaled; may cause skin allergies; suspected mutagen; toxic to aquatic life |
| Ecotoxicity | Requires careful handling to minimize environmental impact |
Why Kajay Remedies’ 4-Aminophenol Stands Out
High purity, stability, and consistency are guaranteed by the strict quality control used in the production of our 4-aminophenol at Kajay Remedies. Perfect for pharmaceutical intermediates, compliant with regulations, and necessary for high-stakes uses like the synthesis of paracetamol, the creation of dyes, and specialty coatings.
In conclusion
4-Aminophenol, also known as para-aminophenol, is a multipurpose substance that connects important sectors, including coatings, dyes, pharmaceuticals, and photography. It is a fundamental specialty chemical due to its broad range of applications and precise functionality.
Kajay Remedies is prepared to collaborate with forward-thinking companies that require dependable supply, superior purity, and knowledgeable assistance when utilizing 4-aminophenol in their formulations.
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Disclaimer:
This article is for informational purposes only and should not be considered medical advice. The signs and symptoms discussed here may vary from person to person. If you experience any of these issues or have concerns about your health, please consult a qualified healthcare professional or neurologist for proper diagnosis and treatment.
I’m Rishabh, the CEO of Meleyrs and a passionate content creator. I specialize in producing clear, fact-based, and informational content across multiple niches, including finance, business, fashion, travel and health tips. My goal is to share accurate knowledge in a way that’s simple, engagingand useful without offering promotions or personal advice.
