4-Aminophenol fundamental organic compound in the chemical industry is aminophenol (para-aminophenol). Its dual functionality—having both an amino (-NH₂) and a hydroxyl (-OH) group on a benzene ring—underlies its adaptability in a variety of applications, including coatings, dyes, and pharmaceuticals.
Chemical Identity & Structure
- IUPAC Name: 4-Aminophenol (para-Aminophenol, p-aminophenol)
- Molecular Formula: C₆H₇NO
- Molecular Weight: ~109.13 g/mol
- CAS Number: 123-30-8
- EC Number: 204-616-2
- Appearance: A white to off-white crystalline powder; moderately soluble in alcohols and water, and prone to oxidation under air, moisture, or light.
- Structural Highlights: The para positioning (1,4 arrangement) of the amine and hydroxyl groups makes it one of three aminophenol isomers (others being ortho- and meta-).
Synthesis Methods
The conventional method involves employing iron and acid to reduce nitrated phenol compounds, such as p-nitrophenol.
The modern method is the one-step, more environmentally friendly catalytic hydrogenation of nitrobenzene in acidic media using noble metal catalysts.
Key Applications of 4-Aminophenol
1. Pharmaceutical Industry:
- Paracetamol (acetaminophen), one of the most popular analgesics and antipyretics in the world, requires it as a precursor.
- Other Drugs: Used in the production of sorafenib, ambroxol, and acebutolol, among other downstream pharmaceutical ingredients.
2. Photography
- 4-aminophenol, marketed under the name Rodinal, is a traditional black-and-white film developing agent that is prized for its image quality and stability.
- Serves as a key building block for azo dyes via diazotization and coupling, widely used in textiles, inks, and plastics for vivid, long-lasting color.
4. Coatings & Corrosion Protection
- In coatings technology, para-aminophenol enhances adhesion, durability, and corrosion resistance—especially in demanding sectors like automotive, aerospace, marine, and construction.
5. Other Industrial Roles
- Acts as a corrosion inhibitor in paints and lubricants, and as a wood stain imparting a rose-like tint.
- Employed as a reagent in analytical chemistry for detecting metals (e.g., copper, vanadium) and compounds such as nitrites and cyanates.
6. Hair Dye Industry
- Used as a precursor in oxidative hair dyes, typically limited to a maximum concentration of ~0.9% when mixed with oxidizing agents to ensure safety and efficacy.
Physicochemical Properties & Safety Profile
| Property | Value / Details |
| Melting Point | ~190 °C |
| Boiling Point | ~284 °C (with decomposition) |
| Log P | ~0.04 (slightly hydrophilic) |
| Hazards | Harmful if ingested or inhaled; may cause skin allergies; suspected mutagen; toxic to aquatic life |
| Ecotoxicity | Requires careful handling to minimize environmental impact |
Why Kajay Remedies’ 4-Aminophenol Stands Out
High purity, stability, and consistency are guaranteed by the strict quality control used in the production of our 4-aminophenol at Kajay Remedies. Perfect for pharmaceutical intermediates, compliant with regulations, and necessary for high-stakes uses like the synthesis of paracetamol, the creation of dyes, and specialty coatings.
In conclusion
4-Aminophenol, also known as para-aminophenol, is a multipurpose substance that connects important sectors, including coatings, dyes, pharmaceuticals, and photography. It is a fundamental specialty chemical due to its broad range of applications and precise functionality.
Kajay Remedies is prepared to collaborate with forward-thinking companies that require dependable supply, superior purity, and knowledgeable assistance when utilizing 4-aminophenol in their formulations.
I’m Rishabh, the CEO of Meleyrs and a passionate content creator. I specialize in producing clear, fact-based, and informational content across multiple niches, including finance, business, fashion, travel and health tips. My goal is to share accurate knowledge in a way that’s simple, engagingand useful without offering promotions or personal advice.
